Abtract:
We consider a tumor formed by a population of n cancerous cells that can be homogeneous or heterogeneous with two degrees of heterogeneity: low (2-type population) or high (3-type population). Our results show that the fitness of the most aggressive cell in the 2-type population game is higher than that of a cell in the 1-type homogeneous population game. Surprisingly, the fitness of the most aggressive cell decreases in the 3-type population. We translate and test these mathematical findings to the field of oncology.

Co écrit avec Andre Rocha, Claudia Manini, Jose Ignacio Lopez et Elena Iñarra.