Benoit PONS : « Ecologie et évolution de la résistance aux phages par CRISPR-Cas »
Benoit PONS
Chercheur postdoctoral
Environment and Sustainability Institute, University of Exeter - Penryn, Royaume-Uni
Équipe CRISPR - Pr Stineke van Houte/Pr Edze Westra
Mots-clefs : interactions phages-bactéries, systèmes de défense bactériens, anti-CRISPR, antibiotiques inhibiteurs de traduction, microfluidique
During my PhD (ToxAlim, Université de Toulouse, France), I characterised the biochemical activity of the Cytolethal Distending Toxin, a genotoxin produced by pathogenic bacteria. I joined Dr van Houte’s group to work on bacteriophages-encoded proteins (anti-CRISPR proteins, Acr) that inhibit bacterial CRISPR-Cas systems. My project focuses aims to better understand how Acr biochemical activity shapes phage-bacteria relationship and impacts coevolution between the virus and its host.